Treatment of resistance to thyroid hormone--primum non nocere.
نویسندگان
چکیده
Resistance to thyroid hormone (RTH) is a dominantly inherited condition of impaired tissue responsiveness to thyroid hormone (TH). Of variable severity, the presence of goiter, tachycardia, hyperactivity, or abnormal findings on routine laboratory tests usually lead to further investigation and, ultimately, the diagnosis of RTH. Characteristic thyroid function tests are elevated free thyroxine (FT4) and free triiodothyronine (FT3) concentrations with nonsuppressed thyrotropin (TSH). Despite the high serum TH levels, TSH responds to stimulation with TSH-releasing hormone, and the doses of TH required to suppress TSH and to produce metabolic effects on peripheral tissues are higher than normal (1). The incidence of RTH is probably 1 case per 50,000 live births (2), with over 600 known cases [(3) and personal information].
منابع مشابه
Growth and Development in a incidentally diagnosed Resistance to Thyroid Hormone
Resistance to thyroid hormone is an uncommon condition. We report the clinical and laboratory findings of a case with both resistance to thyroid hormone and, a reduced capacity to produce and respond to thyroid hormone. RTH is a disorder characterized by elevated circulating thyroid hormones, state of non-suppressed pituitary TSH secretion and refractoriness to hormone action in peripheral tiss...
متن کاملJaundice and factor VII deficiency in newborn
Resistance to thyroid hormone is an uncommon condition. We report the clinical and laboratory findings of a case with both resistance to thyroid hormone and, a reduced capacity to produce and respond to thyroid hormone. RTH is a disorder characterized by elevated circulating thyroid hormones, state of non-suppressed pituitary TSH secretion and refractoriness to hormone action in peripheral tiss...
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ورودعنوان ژورنال:
- The Journal of clinical endocrinology and metabolism
دوره 84 2 شماره
صفحات -
تاریخ انتشار 1999